2-Amino-6-fluorobenzonitrile → N-(4-((3-Amino-2-cyanophenoxy)methyl)cyclohexyl)isonicotinamide

HRID 1467106Notes

Reaction equation

HRID 1467106 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH2:5][CH2:4]1.[NH2:18][C:19]1[CH:26]=[CH:25][CH:24]=[C:23](F)[C:20]=1[C:21]#[N:22]>>[NH2:18][C:19]1[C:20]([C:21]#[N:22])=[C:23]([CH:24]=[CH:25][CH:26]=1)[O:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 66746905N-(4-(Hydroxymethyl)cyclohexyl)isonicotinamide

Product 1

HCID 66745739N-(4-((3-Amino-2-cyanophenoxy)methyl)cyclohexyl)isonicotinamide

Procedure

Prepared as in Example 22b from N-(4-(Hydroxymethyl)cyclohexyl)isonicotinamide (Example 108c) and 2-amino-6-fluorobenzonitrile as a colorless oil (6%). MS 351 (MH+).

Sources & evidence

ORD record
ord-9543a371dd544da7bde852354b4b45d0
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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