Cyclohexanol, 2-methoxy- → 2-Amino-6-(2-methoxycyclohexyloxy)benzonitrile

HRID 1467109Notes

Reaction equation

HRID 1467109 reaction equation
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[OH:9].[NH2:10][C:11]1[CH:18]=[CH:17][CH:16]=[C:15](F)[C:12]=1[C:13]#[N:14]>>[NH2:10][C:11]1[CH:18]=[CH:17][CH:16]=[C:15]([O:9][CH:4]2[CH2:5][CH2:6][CH2:7][CH2:8][CH:3]2[O:2][CH3:1])[C:12]=1[C:13]#[N:14]

Participants

3

Reactant 2

HCID 102911Cyclohexanol, 2-methoxy-HCID 5226592-Amino-6-fluorobenzonitrile

Product 1

HCID 667466302-Amino-6-(2-methoxycyclohexyloxy)benzonitrile

Procedure

Prepared as in Example 22b from 2-methoxycyclohexanol and 2-amino-6-fluoro-benzonitrile as a yellow oil (34%). MS 247 (MH+).

Sources & evidence

ORD record
ord-6af1b8b9c3b94aea8db8a27e8f381977
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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