HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydro-4H-pyran-4-ol → 2-amino-6-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydro-4H-pyran-4-ol | HCID 74956 | — |
| Reactant | 2-Amino-6-fluorobenzonitrile | HCID 522659 | — |
| Product | 2-amino-6-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile | HCID 66745938 | — |
Reaction Steps
Prepared as in Example 22b from tetrahydro-2H-pyran-4-ol and 2-amino-6-fluorobenzonitrile as a colorless oil (48%). 1H NMR (400 MHz, CDCl3) δ 1.87 (m, 2H), 2.00 (m, 2H), 3.63 (m, 2H), 4.00 (m, 2H), 4.42 (s, 2H), 4.58 (m, 1H), 6.23 (d, J=8.4 Hz, 1H), 6.30 (d, J=8.4 Hz, 1H), 7.20 (t, J=8.4 Hz, 1H). MS 219 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09000054B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-c6992dc0847c4a6a94ba9db3122cced5 |
| Source note | uspto-grants-2015_04 |