2-Amino-6-fluorobenzonitrile → HCID 66746918, compound

HRID 1467136Notes

Reaction equation

HRID 1467136 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([CH2:14][OH:15])[CH2:10][CH2:9]2)=[CH:5][CH:4]=1.[NH2:18][C:19]1[CH:26]=[CH:25][CH:24]=[C:23](F)[C:20]=1[C:21]#[N:22]>>[NH2:18][C:19]1[CH:26]=[CH:25][CH:24]=[C:23]([O:15][CH2:14][CH:11]2[CH2:12][CH2:13][N:8]([CH2:7][C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:17][CH:16]=3)[CH2:9][CH2:10]2)[C:20]=1[C:21]#[N:22]

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 54793808HCID 54793808, compound

Product 1

HCID 66746918HCID 66746918, compound

Procedure

Prepared as in Example 22b from (1-(4-methoxybenzyl)piperidin-4-yl)methanol (Example 125c) and 2-amino-6-fluorobenzonitrile as an orange solid (19%). MS 352 (MH+).

Sources & evidence

ORD record
ord-c3ac943b44fd448b9f7aba375533514d
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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