2-Amino-6-fluorobenzonitrile → HCID 66746952, compound

HRID 1467164Notes

Reaction equation

HRID 1467164 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:12])[CH:9]([CH3:11])[CH3:10])[CH2:4][CH2:3]1.[NH2:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18](F)[C:15]=1[C:16]#[N:17]>>[NH2:13][C:14]1[CH:21]=[CH:20][CH:19]=[C:18]([O:1][CH:2]2[CH2:7][CH2:6][N:5]([C:8](=[O:12])[CH:9]([CH3:10])[CH3:11])[CH2:4][CH2:3]2)[C:15]=1[C:16]#[N:17]

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 18340851HCID 18340851, compound

Product 1

HCID 66746952HCID 66746952, compound

Procedure

Prepared as in Example 22a from 1-(4-hydroxypiperidin-1-yl)-2-methylpropan-1-one (Example 143c) and 2-amino-6-fluorobenzonitrile as an off-white solid (87%). MS 288 (MH+).

Sources & evidence

ORD record
ord-694b5e6406ee406c856994f82836bc4d
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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