Propionyl chloride → HCID 66747087, compound

HRID 1467212Notes

Reaction equation

Cl.[N+:2]([C:5]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH2:14][CH:15]2[CH2:19][CH2:18][NH:17][CH2:16]2)[C:6]=1[C:7]#[N:8])([O-:4])=[O:3].[C:20](Cl)(=[O:23])[CH2:21][CH3:22]>>[N+:2]([C:5]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH2:14][CH:15]2[CH2:19][CH2:18][N:17]([C:20](=[O:23])[CH2:21][CH3:22])[CH2:16]2)[C:6]=1[C:7]#[N:8])([O-:4])=[O:3]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 66745747HCID 66745747, compound

Product 1

HCID 66747087HCID 66747087, compound

Procedure

Prepared as in Example 165b from 2-nitro-6-(pyrrolidin-3-ylmethoxy)benzonitrile hydrochloride (Example 181d) and propionyl chloride in 51% as a yellow solid. MS 304 (MH+).

Sources & evidence

ORD record: ord-6707b30077e0430b82660c97ab3b27f0
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

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