Propionyl chloride → HCID 66746686, compound

HRID 1467228Notes

Reaction equation

[Cl-].[C:2]([C:4]1[C:16]([N+:17]([O-])=O)=[CH:15][CH:14]=[CH:13][C:5]=1[O:6][CH2:7][C@@H:8]1[CH2:12][CH2:11][CH2:10][NH2+:9]1)#[N:3].[C:20](Cl)(=[O:23])[CH2:21][CH3:22]>>[NH2:17][C:16]1[CH:15]=[CH:14][CH:13]=[C:5]([O:6][CH2:7][C@@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:20](=[O:23])[CH2:21][CH3:22])[C:4]=1[C:2]#[N:3]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 66747036HCID 66747036, compound

Product 1

HCID 66746686HCID 66746686, compoundYield 90%

Procedure

Prepared as in Example 191a from (S)-2-((2-cyano-3-nitrophenoxy)methyl)pyrrolidinium chloride (Example 191b) and propionyl chloride in 90% yield as a clear syrup. MS 274 (MH+).

Sources & evidence

ORD record: ord-9aaf2d7fe052408cac8bfb615d4e140f
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

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