Ethyl isocyanate → HCID 22381395, compound

HRID 1467249Notes

Reaction equation

HRID 1467249 reaction equation
[NH2:1][CH2:2][C:3]([CH3:7])([CH3:6])[CH2:4][OH:5].[CH2:8]([N:10]=[C:11]=[O:12])[CH3:9]>O1CCOCC1>[CH2:8]([NH:10][C:11]([NH:1][CH2:2][C:3]([CH3:7])([CH3:6])[CH2:4][OH:5])=[O:12])[CH3:9]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 1173261-Propanol, 3-amino-2,2-dimethyl-

Product 1

HCID 22381395HCID 22381395, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 3-amino-2,2-dimethylpropan-1-ol (1.03 g, 10 mmol) in dry 1,4-dioxane (20 mL) was added dropwise ethyl isocyanate (0.71 g, 10 mmol) at room temperature under nitrogen. The reaction mixture was then stirred at room temperature under nitrogen overnight. The solvent was removed under reduced pressure to give the title compound as colorless oil (1.74 g, 100%). MS 175 (MH+).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-9957a4804aa04e428ea2a4a990d7e2ca
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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