Chlorosulfamic acid → HCID 66746175, compound

HRID 1467258Notes

Reaction equation

HRID 1467258 reaction equation
[NH2:1][C:2]1[C:3]([C:17]#[N:18])=[C:4]([CH:14]=[CH:15][CH:16]=1)[O:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12].[S:19](Cl)(=[O:22])(=[O:21])[NH2:20]>>[C:17]([C:3]1[C:2]([NH:1][S:19](=[O:22])(=[O:21])[NH2:20])=[CH:16][CH:15]=[CH:14][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12])#[N:18]

Participants

3

Reactant 2

HCID 24499Chlorosulfamic acidHCID 66746971HCID 66746971, compound

Product 1

HCID 66746175HCID 66746175, compoundYield 100%

Procedure

Prepared as in Example 197a from N-(4-(3-amino-2-cyanophenoxy)butyl)acetamide (Example 210b) and sulfamoyl chloride in 100% yield. 1H NMR (400 MHz, DMSO-d6) δ 1.51-1.54 (m, 2H), 1.70-1.73 (m, 2H), 1.77 (s, 3H), 3.04-3.09 (m, 2H), 4.09 (t, J=6.4 Hz, 2H), 6.93 (d, J=8.4 Hz, 1H), 7.13 (d, J=8.0 Hz, 1H), 7.25 (s, 2H), 7.54 (t, J=8.0 Hz, 1H), 7.85 (brs, 1H), 9.42 (s, 1H).

Sources & evidence

ORD record
ord-2afb2c4aac464dc1a6d4f635f934c0af
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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