Tert-butyl 4-(2-cyano-3-nitrophenoxy)butylcarbamate → HCID 66747054, compound

HRID 1467260Notes

Reaction equation

HRID 1467260 reaction equation
[C:1]([C:3]1[C:21]([N+:22]([O-:24])=[O:23])=[CH:20][CH:19]=[CH:18][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10]C(=O)OC(C)(C)C)#[N:2]>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:10][CH2:9][CH2:8][CH2:7][CH2:6][O:5][C:4]1[CH:18]=[CH:19][CH:20]=[C:21]([N+:22]([O-:24])=[O:23])[C:3]=1[C:1]#[N:2]

Participants

3

Reactant 1

HCID 66665900Tert-butyl 4-(2-cyano-3-nitrophenoxy)butylcarbamate

Product 1

HCID 66747054HCID 66747054, compoundYield 148.4%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of tert-butyl 4-(2-cyano-3-nitrophenoxy)butylcarbamate (Example 210e) (671 mg, 2 mmol) in DCM/TFA (1:1, 20 mL) was stirred at room temperature for 2 hrs. The solvent was removed under vacuum to give the title compound (698 mg, 100%). MS 236 (MH+).

Workup

  1. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-e277ec1752e14be7b362949c30ee2944
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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