Chlorosulfamic acid → 1-(3-(3-Sulfamoylamino-2-cyanophenoxy)-2,2-dimethylpropyl)-3-(4-methoxybenzyl)urea

HRID 1467269Notes

Reaction equation

[NH2:1][C:2]1[C:3]([C:27]#[N:28])=[C:4]([CH:24]=[CH:25][CH:26]=1)[O:5][CH2:6][C:7]([CH3:23])([CH3:22])[CH2:8][NH:9][C:10]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=[O:11].[S:29](Cl)(=[O:32])(=[O:31])[NH2:30]>>[S:29]([NH:1][C:2]1[C:3]([C:27]#[N:28])=[C:4]([CH:24]=[CH:25][CH:26]=1)[O:5][CH2:6][C:7]([CH3:23])([CH3:22])[CH2:8][NH:9][C:10]([NH:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=1)=[O:11])(=[O:32])(=[O:31])[NH2:30]

Participants

Reactant 2

HCID 24499Chlorosulfamic acid

HCID 667462331-(3-(3-Amino-2-cyanophenoxy)-2,2-dimethylpropyl)-3-(4-methoxybenzyl)urea

Product 1

HCID 667473791-(3-(3-Sulfamoylamino-2-cyanophenoxy)-2,2-dimethylpropyl)-3-(4-methoxybenzyl)ureaYield 100%

Procedure

Prepared as in Example 197a from 1-(3-(3-amino-2-cyanophenoxy)-2,2-dimethylpropyl)-3-(4-methoxybenzyl)urea (Example 218b) and sulfamoyl chloride in 100% yield. MS 462 (MH+).

Sources & evidence

ORD record: ord-0745ba6eaefe405fa337c9715cf9c0ca
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09000054B2

Reaction notes

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