tert-Butyl Formate → Tert-butyl 3-((3-amino-2-cyanophenoxy)methyl)piperidine-1-carboxylate

HRID 1467276Notes

Reaction equation

HRID 1467276 reaction equation
[C:1]([C:3]1[C:23]([N+:24]([O-])=O)=[CH:22][CH:21]=[CH:20][C:4]=1[O:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH2:10][N:9]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:8]1)#[N:2].C(OC(C)(C)C)=O>>[NH2:24][C:23]1[C:3]([C:1]#[N:2])=[C:4]([CH:20]=[CH:21][CH:22]=1)[O:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH2:10][N:9]([C:13]([O:15][C:16]([CH3:19])([CH3:17])[CH3:18])=[O:14])[CH2:8]1

Participants

3

Reactant 2

HCID 61207tert-Butyl FormateHCID 66746046Tert-butyl 3-((2-cyano-3-nitrophenoxy)methyl)piperidine-1-carboxylate

Product 1

HCID 66745961Tert-butyl 3-((3-amino-2-cyanophenoxy)methyl)piperidine-1-carboxylateYield 100%

Procedure

Prepared as in example 100b from tert-butyl 3-((2-cyano-3-nitrophenoxy)methyl)piperidine-1-carboxylate (Example 220e) in 100% yield as an oil. MS 232 [M+H-Boc]+.

Sources & evidence

ORD record
ord-b38d35d183374b5d93c97907b28a4129
Source dataset
uspto-grants-2015_04
Patent number
US09000054B2

Reaction notes

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