2-Fluoro-6-methoxybenzaldehyde → HCID 86681281, compound

Participants

Reaction Steps

SODIUM TRIACETOXYBOROHYDRIDE (6.46 g, 30.5 mmol) was added to a stirred mixture of (2S,5R)-methyl 5-(3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamido)-piperidine-2-carboxylate (2 g, 5 mmol) and 2-Fluoro-6-Methoxy-Benzaldehyde (4.70 g, 30.5 mmol) in MeOH (100 ml) and the mixture was stirred at room temperature for overnight. The reaction LCMS gave M+H at 532. The reaction was rotovap to dryness and the residue was purified by column chromatography on silica gel Biotage 40M, eluting with 5% MeOH/NH3(2M)CH2Cl2 to give desired product as a brown solid (2 g, 3.76 mmol, 74.0% yield).

Provenance & Evidence