1,1,1,3,3,3-Hexafluoro-2-propanol → HCID 70653101, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl (3R)-piperidin-3-ylcarbamate (0.1 g, 0.499 mmol), (2-fluorophenyl)boronic acid (0.070 g, 0.499 mmol) and glyoxilic acid monohydrate (0.045 g, 0.499 mmol) were taken up in DCM (2.25 mL)/HFIP (0.25 mL) in a 5 mL microwave vial. The reaction mixture was heated to 120° C. for 15 minutes under microwave irradiation. The solvent was removed in vacuo to give 2-((R)-3-(tert-butoxycarbonylamino)piperidin-1-yl)-2-(2-fluorophenyl)acetic acid as a 1:1 mixture of diastereoisomers.

Provenance & Evidence