Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

N—((R)-1-((S or R)-2-(Dimethylamino)-1-(2-fluorophenyl)-2-oxoethyl)piperidin-3-yl)-3-(pyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide (53 mg, 0.071 mmol) was stirred in TFA (0.5 mL) at room temperature for 30 minutes. triethylsilane (0.015 mL, 0.093 mmol) was added and the reaction mixture diluted with DMF (1 mL). The solution was purified by reverse-phase, mass-triggered prep-HPLC. The product fraction was lyophilized to give the bis TFA salt of N—((R)-1-((S or R)-2-(dimethylamino)-1-(2-fluorophenyl)-2-oxoethyl)piperidin-3-yl)-3-(pyridin-4-yl)-1H-indazole-5-carboxamide as a white solid.

Provenance & Evidence