Diisopropylethylamine → HCID 70652638, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl (3R)-piperidin-3-ylcarbamate (0.234 g, 1.168 mmol), methyl bromo(2,6-difluorophenyl)acetate (0.434 g, 1.636 mmol) and DIPEA (0.612 mL, 3.51 mmol) were taken up in MeCN (11 mL) in a 20 mL microwave vial. The reaction was stirred at 90° C. for 18 hours. Room temperature was attained, and the solvent removed in vacuo. Purification of the residue by MPLC (6-50% EtOAc-hexanes) gave (S)-methyl 2-((R)-3-(tert-butoxycarbonylamino)piperidin-1-yl)-2-(2,6-difluorophenyl)-acetate as a yellow gum and (R)-methyl 2-((R)-3-(tert-butoxycarbonylamino)piperidin-1-yl)-2-(2,6-difluorophenyl)acetate as a yellow gum (R,R).

Provenance & Evidence