Meropenem → Meropenem Trihydrate

Participants

Reaction Steps

Crude meropenem (30 g) (meropenemic acid: 0.37%; meropenem dimer: 0.56%; total impurity content excluding meropenemic acid and meropenem dimer: 0.80%) was dissolved in methanol (120 mL) at 10° C. to 15° C. in a round bottom flask. The solution obtained was treated with carbon (10 g), filtered and cooled to about 10° C. to 15° C. followed by addition of meropenem trihydrate seed crystals (0.075 g) at 12° C. Isopropyl alcohol (200 ml) was added at 0° C. to 10° C. and the filtrate was subjected to aging for further 4 hours at 0° C. to 2° C. The mixture was filtered and washed with acetone (60 ml) and dried for 4 hours to 5 hours at 36° C. to 38° C. under vacuum to obtain the title compound.

Provenance & Evidence