HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malononitrile → Levosimendan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malononitrile | HCID 8010 | — |
| Reactant | Ici 109,081 | HCID 161928 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Product | Levosimendan | HCID 3033825 | — |
Reaction Steps
reacting (−)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone of formula V with sodium nitrite and malononitrile under acidic conditions to obtain levosimendan of formula I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09000158B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-8e5ec90047af492797e696074c797a55 |
| Source note | uspto-grants-2015_04 |