Methyl isothiocyanate → HCID 1269049, compound

HRID 1467653Notes

Reaction equation

HRID 1467653 reaction equation
[C:1]([NH:4][NH2:5])(=[O:3])[CH3:2].[N:6]([CH3:9])=[C:7]=[S:8]>CO>[C:1]([NH:4][NH:5][C:7](=[S:8])[NH:6][CH3:9])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 14039Acetohydrazide

Product 1

HCID 1269049HCID 1269049, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a stirred solution of acetohydrazide (3.7 g, 50 mmol) in methanol (30 mL) was added a solution of compound isothiocyanatomethane (3.65 g, 50 mmol) in methanol (50 mL) at 0° C. After the addition, the mixture was stirred at room temperature overnight. The mixture was concentrated to give crude product (7 g) as a white solid which was used in the next step without further purification. LC-MS (ESI) m/z: 148 (M+1)+.

Workup

  1. additionAfter the addition
  2. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-ff50fc1e1a774ffca8830fd48c7d7bf6
Source dataset
uspto-grants-2015_04
Patent number
US08999987B2

Reaction notes

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