1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione → 5-amino-1,3-dimethylpyrimidine-2,4(1h,3h)-dione

Participants

Reaction Steps

To a stirred solution of 1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione (2.0 g, 10.802 mmol) in methanol (200 mL), 10% Pd—C (0.500 g) was added under hydrogen atmosphere and the reaction mixture was stirred at room temperature for 2 h. Reaction mixture was filtered through a celite bed and washed with methanol. The filtrate was collected and concentrated under reduced pressure to give 1.5 g of the product.

Provenance & Evidence