反应详情

To a stirred suspension of 5-nitro-1,3,6-trimethylpyrimidine-2,4(1H,3H)-dione (4.2 g, 20.084 mmol) in 1:1 mixture of methanol and toluene (200 ml) was added 10% Pd—C (1.2 g). The reaction mixture was stirred under hydrogen atmosphere at room temperature overnight. The mixture was then filtered over a celite bed and was thoroughly washed with methanol (200 ml). The filtrate was collected and evaporated to give viscous residue which was then purified by column chromatography to afford 4.1 g of the product as an off-white solid.

1. filtrationThe mixture was then filtered over a celite bed
2. washwas thoroughly washed with methanol (200 ml)
3. customThe filtrate was collected
4. customevaporated
5. customto give viscous residue which
6. customwas then purified by column chromatography