Sodium hydride → HCID 46947248, compound

Participants

Reaction Steps

The title compound was prepared according to the general procedure (Method A) by coupling Intermediate 1 (50 mg, 0.279 mmol) with 2-bromo-N-[4-(2,3,4-trichlorophenyl)-1,3-thiazol-2-yl]acetamide (134 mg, 0.334 mmol) in the presence of NaH (10 mg, 0.416 mmol) in dry DMF (5.0 mL) to give 37 mg of the product as an off-white solid; 1H NMR (δ ppm, DMSO-d6, 300 MHz) 3.17 (s, 3H), 3.40 (s, 3H), 5.32 (s, 2H), 6.23 (s, 1H), 7.35 (s, 1H), 7.70 (s, 1H), 7.77 (s, 2H), 12.74 (br s, 1H). APCI-MS (m/z) 498.14 (M+H)+.

Provenance & Evidence