Sodium hydride → HCID 46947434, compound

Participants

Reaction Steps

The title compound was prepared according to the general procedure (Method A) by coupling Intermediate 1 (50 mg, 0.279 mmol) with 2-bromo-N-{4-[4-(2-methylpropoxy)-3,5-difluorophenyl]-1,3-thiazol-2-yl}acetamide (135 mg, 0.334 mmol) in the presence of NaH (10 mg, 0.416 mmol) in dry DMF (5.0 mL) to give 45 mg of the product as an off-white solid; 1H NMR (δ ppm, 300 MHz, DMSO-d6) 0.98 (d, J=6.9 Hz, 6H), 1.96-2.04 (m, 1H), 3.17 (s, 3H), 3.33 (s, 3H), 3.91 (d, J=6.3 Hz, 2H), 5.32 (s, 2H), 6.22 (s, 1H), 7.35 (s, 1H), 7.65 (d, J=9.0 Hz, 2H), 7.77 (s, 1H), 12.68 (br s, 1H); APCI-MS (m/z) 504.11 (M+H)+.

Provenance & Evidence