N-Cyclopropyl-N-piperidin-4-yl-3-(trifluoromethyl)benzenesulfonamide → N-cyclopropyl-N-[1-(4-dimethylaminobenzyl)piperidin-4-yl]-3-trifluoromethylbenzenesulfonamide

HRID 1467869Notes

Reaction equation

HRID 1467869 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)(=[O:7])=[O:6])[CH2:3][CH2:2]1.Br[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=1>>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([N:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=3)[CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=2)(=[O:6])=[O:7])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2773944N-Cyclopropyl-N-piperidin-4-yl-3-(trifluoromethyl)benzenesulfonamideHCID 198945934-(bromomethyl)-N,N-dimethylaniline

Product 1

HCID 68984994N-cyclopropyl-N-[1-(4-dimethylaminobenzyl)piperidin-4-yl]-3-trifluoromethylbenzenesulfonamide

Procedure

Similarly, N-cyclopropyl-N-[1-(4-dimethylaminobenzyl)piperidin-4-yl]-3-trifluoromethylbenzenesulfonamide was prepared from N-cyclopropyl-N-piperidin-4-yl-3-trifluoromethylbenzenesulfonamide and 1-bromomethyl-4-dimethylaminobenzene.

Sources & evidence

ORD record
ord-b0975497045b4c6da73428f869d63111
Source dataset
uspto-grants-2015_04
Patent number
US09000174B2

Reaction notes

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