387350-82-5 → HCID 68985907, compound

HRID 1467872Notes

Reaction equation

HRID 1467872 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([CH3:11])[CH:4]=1.[CH:12]1([N:15]([CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:14][CH2:13]1>>[CH:12]1([N:15]([CH:25]2[CH2:30][CH2:29][N:28]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([CH3:11])[CH:4]=3)[CH2:27][CH2:26]2)[S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)(=[O:17])=[O:18])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 2735904387350-82-5HCID 149196094-(Bromomethyl)-1-methoxy-2-methylbenzene

Product 1

HCID 68985907HCID 68985907, compound

Procedure

N-Cyclopropyl-N-[1-(3-methyl-4-methoxybenzyl)piperidin-4-yl]benzenesulfonamide was prepared from 4-bromomethyl-1-methoxy-2-methylbenzene and N-cyclopropyl-N-piperidin-4-yl-benzenesulfonamide according to the above procedure. LC: 100%. MS: m/z=415.2, 416.2 (M+H+). 1H NMR (400 MHz, CDCl3): δ 7.82 (2H, d, J=8.0 Hz), 7.60 (1H, m), 7.52 (2H, m), 7.29 (1H, m), 7.21 (1H, s), 6.85 (1H, d, J=8.8 Hz), 4.13 (2H, s), 4.05 (1H, s), 3.85 (3H, s), 3.54 (2H, m), 2.63 (4H, m), 2.22 (3H, s), 1.75 (3H, m), 0.93 (2H, m), 0.86 (2H, m).

Sources & evidence

ORD record
ord-f4455446cb8241f28f08478e6c5c7b23
Source dataset
uspto-grants-2015_04
Patent number
US09000174B2

Reaction notes

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