N-Cyclopropyl-N-piperidin-4-yl-3-(trifluoromethyl)benzenesulfonamide → HCID 57664567, compound

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Reaction Steps

N-Cyclopropyl-N-{1-[4,4-bis(4-fluorophenyl)-but-3-enoyl]piperidin-4-yl}-3-trifluoromethylbenzenesulfonamide (33) was prepared by reacting N-cyclopropyl-N-piperidin-4-yl-3-trifluoromethylbenzenesulfonamide with 4,4-bis(4-fluorophenyl)-but-3-enoic acid following the procedure described for the synthesis of N-cyclopropyl-N-(2-hexenoyl)piperin-4-yl-3-trifluoromethyl-benzenesulfonamide (30) in Example 19, step a. 1H NMR (CDCl3): δ 8.12 (s, 1H), 8.03 (d, 1H), 7.86 (d, 1H), 7.71 (t, 1H), 7.15 (m, 6H), 6.96 (m, 2H), 6.21 (t, 1H), 4.68 (m, 1H), 4.02 (m, 1H), 3.61 (m, 1H), 3.15 (d, 2H), 2.93 (m, 1H), 2.51 (m, 1H), 1.93 (m, 1H), 1.69 (m, 2H), 1.25 (m, 1H), 0.90 (m, 5H). LC: 100%. MS (M+H+): 605.

Provenance & Evidence