Diphenylpropionic acid → HCID 68985451, compound

HRID 1467884Notes

Reaction equation

HRID 1467884 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)(=[O:7])=[O:6])[CH2:3][CH2:2]1.[C:24]1([CH:30]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:31][C:32](O)=[O:33])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:32](=[O:33])[CH2:31][CH:30]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH2:20][CH2:19]2)[S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=2)(=[O:6])=[O:7])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 64798Diphenylpropionic acidHCID 2773944N-Cyclopropyl-N-piperidin-4-yl-3-(trifluoromethyl)benzenesulfonamide

Product 1

HCID 68985451HCID 68985451, compound

Procedure

N-Cyclopropyl-N-[1-(3,3-diphenylpropanoyl)piperidin-4-yl]-3-trifluoromethylbenzenesulfonamide was prepared from N-cyclopropyl-N-(piperidin-4-yl)-3-trifluoromethylbenzenesulfonamide and 3,3-diphenylpropanoic acid. LC: 100%. MS: m/z=557 (M+H+). 1H NMR (CDCl3): δ 8.11 (1H, s), 8.02 (1H, d), 7.84 (1H, d), 7.70 (1H, t), 7.23 (10H, m), 4.64 (2H, m), 3.98 (1H, m), 3.85 (1H, d), 3.00 (2H, m), 2.82 (1H, t), 2.37 (1H, t), 1.86 (1H, m), 1.60 (4H, m), 0.91 (1H, m), 0.72 (3H, m);

Sources & evidence

ORD record
ord-e0c19382c9c34cdc9a64c37880c5d405
Source dataset
uspto-grants-2015_04
Patent number
US09000174B2

Reaction notes

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