Water → HCID 57664590, compound

Participants

Reaction Conditions

Reaction Steps

1-[Bis(4-fluorophenyl)-methoxy]-2-iodoethane (36) (294 mg, 0.79 mmol) was dissolved in 5 mL of methyl ethyl ketone and the mixture was added to N-cyclopropyl-N-(4-piperidinyl)-3-(trifluoromethyl)benzenesulfonamide (200 mg, 0.57 mmol) and K2CO3 (157 mg, 1.1 mmol). The mixture was then heated at 80° C. overnight. Water was added to the mixture, and EtOAc was used to extract the product. The organic layer was dried over Na2SO4 and evaporated. The crude product was purified by silica gel column eluting with CH2Cl2 and CH2Cl2/EtOAc (4:1) to afford the title compound 38 as a yellow oil. 1H NMR (CDCl3): δ 8.127 (s, 1H), 8.061-8.042 (d, 1H), 7.856-7.833 (d, 1H), 7.694-7.655 (t, 1H), 7.282-7.233 (m, 4H), 7.035-6.972 (m, 4H), 5.302 (s, 1H), 3.882-3.806 (t, 1H), 3.551-3.491 (t, 2H), 2.965-2.887 (d, 2H), 2.670-2.605 (t, 2H), 2.127-2.064 (t, 2H), 1.986-1.939 (m, 3H), 1.531-1.493 (d, 2H), 0.992-0.952 (m, 2H), 0.794-0.760 (m, 2H). LC: 100%. MS (e/z): 596 (M+H+).

Provenance & Evidence