3,5-Difluoropyridine-4-carbaldehyde → (3,5-Difluoropyridin-4-yl)methanol

HRID 1467904Notes

Reaction equation

HRID 1467904 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:10])[C:7]=1[CH:8]=[O:9]>CO>[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9]

Participants

3

Reactant 1

HCID 116511703,5-Difluoropyridine-4-carbaldehyde

Product 1

HCID 66815317(3,5-Difluoropyridin-4-yl)methanolYield 73%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Title compound was prepared by a method analogous to that described for Intermediate 7, replacing 3,4-difluoro-2-pyridinecarbaldehyde with 3,5-difluoro-4-pyridinecarbaldehyde (FRONTIER) and using MeOH as solvent. (200 mg, 1.398 mmol, 73% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm: 8.51 (s, 2H), 5.55 (t, 1H), 4.55-4.57 (m, 2H). [ES+MS] m/z 146 (MH+).

Sources & evidence

ORD record
ord-c121df29745840fb97cb226c93747f1f
Source dataset
uspto-grants-2015_04
Patent number
US09000181B2

Reaction notes

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