Potassium Phosphate, Tribasic → HCID 51038617, compound

Participants

Reaction Conditions

Reaction Steps

1 mmol of 3-(4-bromophenyl)-1-(pyridin-2-yl)-1H-pyrazol-5-yl tert-butyl carbonate (21) prepared in Example B-2 was charged in a 50 mL round-bottom flask and dissolved in 1,4-dioxane (10 mL), and phenylboronic acid (2.5 equivalents, manufactured by Aldrich) and K3PO4 (3 equivalents) were added thereto. Thereafter, PdCl2(dppf) (0.08 equivalents, manufactured by Aldrich) and dppf (1,1′-bis(diphenylphosphino)ferrocene, 0.04 equivalents, manufactured by Aldrich) were added thereto, followed by heating at 100° C. for 10 minutes. After the solid was filtered through Celite, the organic layer was concentrated under reduced pressure, dissolved in ethyl acetate and then washed with water. The organic layer was dried over anhydrous MgSO4 and concentrated. The resulting residue was purified by column chromatography (n-hexane:EA (ethyl acetate)=5:1 (v/v)) to afford the title compound.

Provenance & Evidence