Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | HCID 178515626 | HCID 178515626 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 51036477 | HCID 51036477 | — |
Reaction Steps
1 mmol of 3-(4-iodophenyl)-1-(pyridin-2-yl)-1H-pyrazol-5-ol was charged in a 50 mL round-bottom flask and dissolved in 1,4-dioxane (10 mL), and phenylboronic acid (2.5 equivalents, manufactured by Aldrich) and K3PO4 (3 equivalents) were added thereto. Thereafter, PdCl2(dppf) (0.08 equivalents, manufactured by Aldrich) and dppf (1,1′-bis(diphenylphosphino)ferrocene, 0.04 equivalents, manufactured by Aldrich) were added thereto, followed by heating at 100° C. for 10 minutes. After the solid was filtered through Celite, the organic layer was concentrated under reduced pressure, dissolved in ethyl acetate and then washed with water. The organic layer was dried over anhydrous MgSO4 and concentrated. The resulting residue was purified by column chromatography (n-hexane:EA=8:1 (v/v)) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09000176B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
|---|
| ORD ID | ord-d084c2a24b1140a79d4185a924c9228c |
|---|
| Source note | uspto-grants-2015_04 |
|---|
