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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1467965Generated: October 31, 2026

2-Chloro-5-hydroxypyridine → cis(+/-)-tert-Butyl-4-((6-chloropyridin-3-yl)oxy)-3-fluoropiperidine-1-carboxylate

https://huagongshe.com/reaction/1467965

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-hydroxypyridineHCID 819821—
Reactantrac-tert-butyl (3R,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylateHCID 40152150—
Productcis(+/-)-tert-Butyl-4-((6-chloropyridin-3-yl)oxy)-3-fluoropiperidine-1-carboxylateHCID 131732698—

Reaction Steps

The title compound was prepared by following the similar procedure as described in Intermediate-1, using 6-chloropyridin-3-ol and trans(±)-tert-butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate (0.490 g, 48%); MS: 332.2 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000175B2
Source datasetuspto-grants-2015_04
ORD IDord-21fd667afeb04480b5c3330f35416118
Source noteuspto-grants-2015_04