Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1467978Generated: October 25, 2026

Ethyl indole-5-carboxylate → Ethyl-1-(5-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-2-yl)-1H-indole-5-carboxylate

https://huagongshe.com/reaction/1467978

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-5-carboxylateHCID 10987040—
ReactantTert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylateHCID 86696180—
ProductEthyl-1-(5-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-2-yl)-1H-indole-5-carboxylateHCID 67617454—

Reaction Steps

The title compound was prepared by following the similar procedure as described in Intermediate-27 using tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate and ethyl 1H-indole-5-carboxylate (0.21 g, 36%); MS: 466.2 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000175B2
Source datasetuspto-grants-2015_04
ORD IDord-4a00d9f372f443a283eeb28ec303b161
Source noteuspto-grants-2015_04