2,4-Dibromo-1,3-thiazole → HCID 67608573, compound

HRID 1467990Notes

Reaction equation

HRID 1467990 reaction equation
[CH2:1]([C:3]1[N:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([OH:15])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].Br[C:17]1[S:18][CH:19]=[C:20]([Br:22])[N:21]=1>>[Br:22][C:20]1[N:21]=[C:17]([O:15][CH:12]2[CH2:13][CH2:14][N:9]([C:6]3[CH:5]=[N:4][C:3]([CH2:1][CH3:2])=[CH:8][N:7]=3)[CH2:10][CH2:11]2)[S:18][CH:19]=1

Participants

3

Reactant 2

HCID 27632972,4-Dibromo-1,3-thiazoleHCID 67608386HCID 67608386, compound

Product 1

HCID 67608573HCID 67608573, compound

Procedure

The title compound was prepared by following the similar procedure as described in Intermediate-42 using 1-(5-ethylpyrazin-2-yl)piperidin-4-ol and 2,4-dibromothiazole (0.480 g, 54%); MS: 369.2 (M+1).

Sources & evidence

ORD record
ord-aeff33fc91744390aed4c139eb2cd541
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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