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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1468003Generated: October 31, 2026

2-Chloro-5-hydroxypyridine → trans(+/-)-Tert-butyl-4-((6-chloropyridin-3-yl)oxy)-3-fluoropiperidine-1-carboxylate

https://huagongshe.com/reaction/1468003

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-hydroxypyridineHCID 819821—
Reactanttert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylateHCID 40152152—
Producttrans(+/-)-Tert-butyl-4-((6-chloropyridin-3-yl)oxy)-3-fluoropiperidine-1-carboxylateHCID 131732699—

Reaction Steps

The title compound was prepared by following the similar procedure as described in Intermediate-6 using 6-chloropyridin-3-ol and cis(±)tert-butyl-3-fluoro-4-hydroxypiperidine-1-carboxylate; MS: 353.2 (M+23).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000175B2
Source datasetuspto-grants-2015_04
ORD IDord-859265be658543029b99f8d9f2b50d53
Source noteuspto-grants-2015_04