Chloroacetyl chloride → 1-(Chloroacetyl)pyrrolidine

Participants

Reaction Steps

To an ice-cooled solution of pyrrolidine (0.4 g, 5.62 mmol) in dichloromethane (4 mL), triethylamine (1.176 mL, 8.44 mmol) and chloroacetyl chloride (0.451 mL, 5.62 mmol) was added. The resulting mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with dichloromethane and washed with water. The organic layer was concentrated in vacuo and residue was purified by column chromatography to give title compound (0.5 g, 60.2%); MS: 147.10 (M+).

Provenance & Evidence