5-methoxy-1H-pyrrolo[2,3-b]pyridine → tert-Butyl-4-((6-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-1-yl)pyridin-3-yl)oxy)-piperidine-1-carboxylate
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH:11]=[CH:10][NH:9][C:6]2=[N:7][CH:8]=1.Cl[C:13]1[N:18]=[CH:17][C:16]([O:19][CH:20]2[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]2)=[CH:15][CH:14]=1>>[C:29]([O:28][C:26]([N:23]1[CH2:22][CH2:21][CH:20]([O:19][C:16]2[CH:17]=[N:18][C:13]([N:9]3[C:6]4=[N:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=[C:5]4[CH:11]=[CH:10]3)=[CH:14][CH:15]=2)[CH2:25][CH2:24]1)=[O:27])([CH3:32])([CH3:30])[CH3:31]Participants
3
Procedure
The title compound was prepared by following the similar procedure as described in Intermediate-27 using 5-methoxy-1H-pyrrolo[2,3-b]pyridine and tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate. (0.09 g, 45%); MS: 425(M+1).
Sources & evidence
- ORD record
- ord-d8a5dba68c26465e919991ce1b50fa92
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09000175B2
Reaction notes
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