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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1468015Generated: October 26, 2026

5-(Methylsulfonyl)-1H-indole → tert-Butyl-4-(4-(5-(methylsulfonyl)-1H-indol-1-yl)phenoxy)-piperidine-1-carboxylate

https://huagongshe.com/reaction/1468015

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Methylsulfonyl)-1H-indoleHCID 14973230—
Reactant1-BOC-4-(4-bromophenoxy)piperidineHCID 46739006—
Producttert-Butyl-4-(4-(5-(methylsulfonyl)-1H-indol-1-yl)phenoxy)-piperidine-1-carboxylateHCID 67807115—

Reaction Steps

The title compound was prepared by following the similar procedure as described in Example-1 by using 5-(methylsulfonyl)-1H-indole (intermediate-21) and tert-butyl-4-(4-bromophenoxy)piperidine-1-carboxylate (intermediate-77) (0.130 g, 24%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000175B2
Source datasetuspto-grants-2015_04
ORD IDord-6819bad5f2ff4cb986d8d9c7586376d1
Source noteuspto-grants-2015_04