HCID 22103818, compound → HCID 67808992, compound

HRID 1468032Notes

Reaction equation

HRID 1468032 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[CH:8]2)=[O:4].Cl[C:15]1[N:20]=[CH:19][C:18]([O:21][CH2:22][CH:23]2[CH2:28][CH2:27][N:26]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:25][CH2:24]2)=[CH:17][CH:16]=1>>[C:32]([O:31][C:29]([N:26]1[CH2:27][CH2:28][CH:23]([CH2:22][O:21][C:18]2[CH:19]=[N:20][C:15]([N:10]3[C:11]4[C:7](=[CH:6][C:5]([C:3](=[O:4])[NH:2][CH3:1])=[CH:13][CH:12]=4)[CH:8]=[CH:9]3)=[CH:16][CH:17]=2)[CH2:24][CH2:25]1)=[O:30])([CH3:35])([CH3:33])[CH3:34]

Participants

3

Reactant 2

HCID 22103818HCID 22103818, compoundHCID 59718534tert-Butyl 4-{[(6-chloropyridin-3-yl)oxy]methyl}piperidine-1-carboxylate

Product 1

HCID 67808992HCID 67808992, compound

Procedure

The title compound was prepared by following the similar procedure as described in Example-1 by using N-methyl-1H-indole-5-carboxamide (intermediate-14) and tert-butyl 4-(((6-chloropyridin-3-yl)oxy)methyl)piperidine-1-carboxylate (intermediate-29).

Sources & evidence

ORD record
ord-423ba0c08c994575bab97d63ed27fd78
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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