HCID 63749495, compound → HCID 86696201, compound

HRID 1468034Notes

Reaction equation

HRID 1468034 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[OH:22][CH2:23][CH2:24][NH:25][C:26]([C:28]1[CH:29]=[C:30]2[C:34](=[CH:35][CH:36]=1)[NH:33][CH:32]=[CH:31]2)=[O:27]>>[C:18]([O:17][C:15]([N:12]1[CH2:13][CH2:14][CH:9]([O:8][C:5]2[CH:6]=[N:7][C:2]([N:33]3[C:34]4[C:30](=[CH:29][C:28]([C:26](=[O:27])[NH:25][CH2:24][CH2:23][OH:22])=[CH:36][CH:35]=4)[CH:31]=[CH:32]3)=[CH:3][CH:4]=2)[CH2:10][CH2:11]1)=[O:16])([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 63749495HCID 63749495, compoundHCID 86696180Tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate

Product 1

HCID 86696201HCID 86696201, compound

Procedure

The title compound was prepared by following the similar procedure as described in Example-1 by using tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate (intermediate-6) and N-(2-hydroxyethyl)-1H-indole-5-carboxamide (intermediate-19) (0.110 g, 48.0%).

Sources & evidence

ORD record
ord-96da2764f0c7445da744ac9fd833842d
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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