5-(Methylsulfonyl)-1H-indole → HCID 67808776, compound

HRID 1468048Notes

Reaction equation

HRID 1468048 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[CH:8]2)(=[O:4])=[O:3].[C:14]([O:18][C:19]([N:21]1[CH2:26][CH2:25][CH:24]([NH:27][CH2:28][C:29]2[CH:30]=[N:31][C:32](Cl)=[CH:33][CH:34]=2)[CH2:23][CH2:22]1)=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19]([N:21]1[CH2:22][CH2:23][CH:24]([NH:27][CH2:28][C:29]2[CH:30]=[N:31][C:32]([N:10]3[C:11]4[C:7](=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:13][CH:12]=4)[CH:8]=[CH:9]3)=[CH:33][CH:34]=2)[CH2:25][CH2:26]1)=[O:20])([CH3:17])([CH3:15])[CH3:16]

Participants

3

Reactant 2

HCID 149732305-(Methylsulfonyl)-1H-indole2×HCID 59718569HCID 59718569, compound2×

Product 1

HCID 67808776HCID 67808776, compound

Procedure

The title compound was prepared by following the similar procedure as described in example-1 using 5-(methylsulfonyl)-1H-indole (intermediate 21) and tert-butyl-4-(((6-chloropyridin-3-yl)methyl)amino)piperidine-1-carboxylate (intermediate 79).

Sources & evidence

ORD record
ord-474444fb82d949d6b4306249d41cb715
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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