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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1468051Generated: November 2, 2026

5-(Methylsulfonyl)-1H-indole → cis (+/-)-tert-Butyl-3-fluoro-4-((6-(5-(methylsulfonyl)-1H-indol-1-yl)-pyridin-3-yl)oxy)piperidine-1-carboxylate

https://huagongshe.com/reaction/1468051

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Methylsulfonyl)-1H-indoleHCID 14973230—
Reactantcis(+/-)-tert-Butyl-4-((6-chloropyridin-3-yl)oxy)-3-fluoropiperidine-1-carboxylateHCID 131732698—
Productcis (+/-)-tert-Butyl-3-fluoro-4-((6-(5-(methylsulfonyl)-1H-indol-1-yl)-pyridin-3-yl)oxy)piperidine-1-carboxylateHCID 89805092—

Reaction Steps

The title compound was prepared by following the similar procedure as described in Example-1 by using 5-(methylsulfonyl)-1H-indole (intermediate 21) and cis(±)-tert-butyl-4-((6-chloropyridin-3-yl)oxy)-3-fluoropiperidine-1-carboxylate (intermediate 7).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09000175B2
Source datasetuspto-grants-2015_04
ORD IDord-a69e36418230449091fe1dbbf489c4ae
Source noteuspto-grants-2015_04