5-(1H-1,2,4-triazol-1-yl)-1H-indole → tert-Butyl 4-((6-(5-(1H-1,2,4-triazol-1-yl)-1H-indol-1-yl)pyridin-3-yl) oxy)piperidine-1-carboxylate

HRID 1468058Notes

Reaction equation

HRID 1468058 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[N:22]1([C:27]2[CH:28]=[C:29]3[C:33](=[CH:34][CH:35]=2)[NH:32][CH:31]=[CH:30]3)[CH:26]=[N:25][CH:24]=[N:23]1>>[N:22]1([C:27]2[CH:28]=[C:29]3[C:33](=[CH:34][CH:35]=2)[N:32]([C:2]2[N:7]=[CH:6][C:5]([O:8][CH:9]4[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]4)=[CH:4][CH:3]=2)[CH:31]=[CH:30]3)[CH:26]=[N:25][CH:24]=[N:23]1

Participants

3

Reactant 2

HCID 676168785-(1H-1,2,4-triazol-1-yl)-1H-indole2×HCID 86696180Tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate

Product 1

HCID 86696207tert-Butyl 4-((6-(5-(1H-1,2,4-triazol-1-yl)-1H-indol-1-yl)pyridin-3-yl) oxy)piperidine-1-carboxylate

Procedure

The title compound was prepared by following the similar procedure as described in Example-1 using tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate (intermediate-6) and 5-(1H-1,2,4-triazol-1-yl)-1H-indole (intermediate 58) (0.440 g, 29%).

Sources & evidence

ORD record
ord-cfa06b826fc049efb0ea44d1d9aa7392
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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