Potassium Iodide → HCID 67807850, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-chloro-1-(pyrrolidin-1-yl)ethanone (Intermediate 71) (0.055 g, 0.366 mmol) in DMF (2 mL), potassium iodide (0.023 g, 0.137 mmol), 5-(methylsulfonyl)-1-(5-(piperidin-4-yloxy)pyridin-2-yl)-1H-indole (0.170 g, 0.458 mmol) and potassium carbonate (0.064 g, 0.458 mmol) were added. The resulting mixture was heated at 80° C. for 45 minutes. Reaction was quenched with water and extracted with ethyl acetate. The organic extract was concentrated in vacuo and resultant residue was purified by column chromatography to yield title compound (0.075 g, 33.3%).

Provenance & Evidence