5-(Methylsulfonyl)-1H-indole → HCID 67615520, compound

HRID 1468064Notes

Reaction equation

HRID 1468064 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[CH:8]2)(=[O:4])=[O:3].Br[C:15]1[N:16]=[C:17]([O:20][CH2:21][CH:22]2[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]2)[S:18][CH:19]=1>>[C:31]([O:30][C:28]([N:25]1[CH2:24][CH2:23][CH:22]([CH2:21][O:20][C:17]2[S:18][CH:19]=[C:15]([N:10]3[C:11]4[C:7](=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:13][CH:12]=4)[CH:8]=[CH:9]3)[N:16]=2)[CH2:27][CH2:26]1)=[O:29])([CH3:34])([CH3:32])[CH3:33]

Participants

3

Reactant 2

HCID 149732305-(Methylsulfonyl)-1H-indoleHCID 86696190HCID 86696190, compound2×

Product 1

HCID 67615520HCID 67615520, compound

Procedure

The title compound was prepared by following the similar procedure as described in Example-1 by using 5-(methylsulfonyl)-1H-indole (intermediate-21) and tert-Butyl 4-(((4-bromothiazol-2-yl)oxy)methyl)piperidine-1-carboxylate (intermediate 47) (0.013 g, 10%).

Sources & evidence

ORD record
ord-c602af78f9534ad68d1a9a20ecdfe3a7
Source dataset
uspto-grants-2015_04
Patent number
US09000175B2

Reaction notes

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