Hydrochloric Acid → HCID 86706696, compound

Participants

Reaction Steps

HCl-solution (4 M in 1,4-dioxane, 4.76 mL, 19.0 mmol) was added to a solution of N-(5′-bromo-4-methoxy-6′-methylspiro[cyclohexane-1,2′-indene]-3′(1′H)-ylidene)-2-methylpropane-2-sulfinamide (Intermediate 9, 812 mg, 1.90 mmol) in anhydrous 1,4-dioxane (8 mL). The resulting mixture was stirred under a nitrogen atmosphere at r.t. for 1 h. The mixture was concentrated and the residue was dissolved in a small amount of DCM (˜4-6 mL). Et2O (14 mL) was added and the solid was filtered off and washed with Et2O. The solid was partitioned between DCM (10 mL) and saturated aqueous NaHCO3 (8 mL). The phases were separated and the organic layer concentrated. The product (446 mg) was used directly in the next step: MS (EI) m/z 321, 323 [M+.].

Provenance & Evidence