Hydrochloric Acid → HCID 86706698, compound

Participants

Reaction Steps

HCl (4 M in 1,4-dioxane) (7.84 mL, 31.4 mmol) was added to a solution of N-(5′-bromo-6′-fluoro-4-methoxyspiro[cyclohexane-1,2′-indene]-3′(1′H)-ylidene)-2-methylpropane-2-sulfinamide (Intermediate 12, 1.35 g, 3.14 mmol) in anhydrous 1,4-dioxane (23 mL) and the resulting mixture was stirred under an argon atmosphere for 15 min. Et2O (60 mL) was added and the precipitate was filtered off and washed with Et2O, then partitioned between DCM and saturated aqueous NaHCO3. The phases were separated, the organic phase dried over sodium sulfate and concentrated to give the title compound (0.95 g, 93% yield) that was used without further purification. MS (ES+) m/z 326, 328 [M+H]+.

Provenance & Evidence