Cesium carbonate → HCID 86706699, compound

Participants

Reaction Conditions

Reaction Steps

Di-tert-butyl (6′-bromo-5′-fluoro-4-methoxy-5″-methyl-3′H-dispiro[cyclohexane-1,2′-indene-1′,2″-imidazol]-4″-yl)imidodicarbonate (Intermediate 15, 0.261 g, 0.44 mmol), di-tert-butyl(2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl-2-yl)phosphine (0.012 g, 0.03 mmol), cesium carbonate (0.053 mL, 0.66 mmol), allylpalladium chloride dimer (3.1 mg, 8.78 μmol) and 3-fluoropropan-1-ol (0.069 g, 0.88 mmol) were placed in a tube. The tube was capped and inerted by vacuum-nitrogen purge cycles. Toluene (3 mL) was added and the mixture was heated at 90° C. o.n. More 3-fluoropropan-1-ol (0.069 g, 0.88 mmol) was added, and the reaction was heated for another 3 h. The mixture was allowed to cool to r.t. and was then filtered and concentrated. The product was used directly in the next step.

Provenance & Evidence