Hydrochloric Acid → 2-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-ethanone hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	{4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-6,7-dimethoxy-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester	HCID 68612821	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	2-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-ethanone hydrochloride	HCID 68613583	99%

Reaction Steps

As described in Example 1, 84 mg of {4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-6,7-dimethoxy-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 74 mg (99%) of 2-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-ethanone hydrochloride. MS: APCI (M+H) calc'd for C23H25N3O3+H 392.5; found 392.1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07732446B1
Source dataset	uspto-grants-2010_06
ORD ID	ord-0dfa6c2a35b54babb8ce412df6e10688
Source note	uspto-grants-2010_06