Hydrazine hydrate (1:1) → 4-Cyanobenzohydrazide

Participants

Reaction Conditions

Reaction Steps

Add hydrazine monohydrate (5.50 mL, 110 mmol) to a solution of methyl 4-cyanobenzoate (3.30 g, 20.5 mmol) in 20 mL of EtOH. Heat the mixture at 80° C. for 1 h resulting in a solution. Cool the mixture to room temperature, causing a solid to precipitate from solution. Collect the precipitate by filtration, wash with cold EtOH followed by diethyl ether to provide 1.90 g, 58% yield of 4-cyano-benzoic acid hydrazide as a light yellow solid.

Provenance & Evidence